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Clinacanthus nutans Lindau is known as snake grass belonging to the Acanthaceae family. This plant has diverse and potential medicinal uses. PDF | Clinacanthus nutans is widely known in traditional medicine in Malaysia and Thailand due to its medicinal properties in treating skin rashes, insect and. Family Name: Acanthaceae. Synonyms: Clinacanthus burmanni. Common Names: Sabah Snake Grass. Chinese Name: 优顿草.

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Ezhilan BP, Neelamegam R.

However, no effect was observed in IMR 32 cell lines. Significant inhibition of cell proliferation was shown in HeLa and K cells after treated with the C. Increased free radicals, the reactive oxygen species and lcinacanthus nitrogen species, in cancer cells correlate with the rapid progression to tumour development and promote metastasis, which often results in poor prognosis.

The botanical identify of C.

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Methods and Materials 2. These cancer cells could develop antioxidant defense system with enhanced scavenging capacity and survive intrinsic ROS toxicity through upregulation of survival proteins. However, CNA showed the lowest activity with antioxidant capacity value Although this data suggests that CNC may not be a strong anticancer regimen, the clinaanthus and cancer inhibitory properties demonstrated in this experiment may still support the use of CNC as an alternate adjunctive therapy for cancer prevention or treatment.

Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea.

A small quantity is enough to provide a warm effect within a few minutes. Three different extracts were tested on eight human cancer cell lines, including human liver hepatocellular carcinoma HepG2human neuroblastoma cell line IMRhuman lung cancer cell line NCI-H23human gastric cancer cell line SNU-1human colon adenocarcinoma cell line LSThuman nnutans cell line Khuman cervical cancer cell line HeLahuman Burkitt’s lymphoma cell line Raji and normal cell, and human umbilical veins endothelial cells HUVECs for their antiproliferative activity.


The extracts in all three solvents were collected separately in clean glass bottles. We hypothesize that CN derivatives could be a source of cytoprotective antioxidant based anticancer regimen. Hence, clinacanthuss is still needed to stop ROS from spreading, and its role is more likely to salvage the unaffected cells adjacent to transformed cancer cells and limit tumour expansion.

Clinacanthus Nutans Balm 22g

Free radicals and antioxidants: This balm may also be spread on calves, wrists or on back of neck to reduce risk of insect bites. Therefore, it is possible that scavenging the radicals with exogenous antioxidant alone may not be effective to eliminate the transformed cancer.

The antioxidant activity of the C. At the first use, try the balm on your wrist to detect any allergic reaction. Although constituents in CNC failed to suppress the proliferation of IMR32 cancer cells, the inhibitory benefits could still be observed using extracts in methanol and in water.

It was observed that only CNA has the ability to scavenge nitric oxide radical and was in the concentration dependent manner.

Bulletin of the Department of Medical Sciences. In vitro and clinacatnhus vivo antioxidant activity of aqueous leaves extract of leonotis leonurus L. All the assays were carried out in triplicate and in three independent tests.

Conflict of Interests All authors have no conflict of interests. Acanthaceae Plants described in Acanthaceae stubs. The current treatment for cancer patients, such as chemotherapy and radiotherapy, may also contribute to oxidative damage to the tumour cells as well as the adjacent healthy cells.


Our data showed flinacanthus CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals.

A partner in daily life. In front of disease, the purpose is to consider that the patient seeks to restore the balance by focusing on 3 ways:.

Please review our privacy policy. However the use has also been limited by genomic instability and drug resistance characteristics in certain cancer cells. Discussion Past studies have shown that imbalance cellular redox homeostasis with elevated free radical production is one of the common causes of cancer initiation and progression and many other diseases [ 21 ]. Also available in 65g bottle. Annual Review of Pharmacology and Toxicology. Thus, scavenging the free radicals with antioxidant may prove an alternate strategy to protect normal healthy cells from DNA damage and limit the progression of cancer cells.

See Description tab to know detailed specs of our balms. In order to determine the galvinoxyl radical scavenging activity of each extract. DMSO in distilled water 0. Apply a nut of balm on skin. Recent report from Pannangpetch et al. The role of nitric oxide in cancer.

Open in a separate window. Reactive oxygen species in tumor progression.