Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. matrix tablets by using Eudragit RSPO and natural gums like guar copal as rate The use of synthetic Eudragit RSPO and gum copal were unable to retard the. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.
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Compression was carried out using 14 mm flat faced circular punches into tablets on an eight station rotary press tablet compression machine Rimek Minipress I Ahmadabad, India at a constant compression force. The dissolution test was performed in triplicate. The tablets were prepared by wet granulation method. The data were analyzed by the regression coefficient method and regression coefficient values r 2 of all batches were shown in Table 4. Side effects, short half lives, low bioavailability and the need for the administration two to three times a day when larger doses are required can decrease patient compliance.
D response surface plots showing the effect of a ratio of a polymer to a drug and concentration of a surfactant at constant sonication time and b ratio of a polymer to a drug and sonication time at constant concentration of a surfactant.
Matrix systems are widely used in oral controlled drug delivery because of their flexibility, cost effectiveness, low influence of the physiological variables on its release behavior and broad regulatory acceptance [ 67 ]. The in vitro dissolution study was carried out using USP 22 apparatus I, paddle method and the data was analysed using zero order, first order, Higuchi, Korsmeyer and Hixson-Crowell equations. Other Engineering Material Material Notes: Introduction Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults.
The reduction in zeta potential is attributed to the effect of the shift in the plane of shear away from the particle surface [ 39 ]. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below.
Their results indicated that the drug had a solubility of Normally the ratio greater than 4 is desirable for the model to be used effectively [ 28 ]. These kinds of plots are useful in studying the effects of two independent factors on the response at one time [ 30 ].
It is a solid substance in form of white powder with a faint amine-like odour. Diffusion coupled with erosion might be the mechanism for the drug release from hydrophilic and hydrophobic polymer based matrix tablets which can be expected to reduce the frequency of administration and decrease the dose-dependent side effects associated with repeated administration of conventional metformin HCl Tablets.
The interactions between ratio of a polymer to a drug and concentration of a surfactant and ratio of a polymer to a drug and sonication time were also statistically significant on EE. Questions or comments about MatWeb?
The reduced model for PDI is presented in where and are ratio of a polymer to a drug and concentration of a surfactant, respectively. To receive news and publication updates for Journal of Nanomaterials, enter your email address in the box below.
Evonik EUDRAGIT® RS PO Copolymer
Various formulation and process variables such as amount of polymer, concentration of surfactant, amount of drug, stirring speed, stirring time, and temperature play a key role in determining the final physical and mechanical characteristics of nanoparticles. The coefficient of determination of the model for mean particle size was 0. Methacrylic resins Eudragit appear particularly attractive due to their high chemical stability and compactility properties, and many literatures substantiate use in the development of control release matrix tablet [ 1213 ].
The results are similar to the results published by various researchers [ 22 ] that the zeta potential decreases at high level of ratio of a polymer to a drug. In each formulation, the amount of the active ingredient is mg and the total weight of a tablet is mg. The wide applications of GC and GD propose their strong hydrophobic nature, substantial binding property, compatibility with the physiologic environment [ 17 ] and their sustaining property [ 18 ]. In order to confirm the predicted results, the predicted and experimental results were compared as shown in Table 8.
Nanoprecipitation of hydrophobic drugs is more facile than the hydrophilic ones. It is also known as solvent displacement or interfacial deposition method and was developed about 40 years ago [ 18 ].
Journal of Nanomaterials
Drug release from GC and GD matrix followed zero order and Higuchi square root kinetics respectively. While in the systemic circulation the nanoparticles extend the half-life of the drug and release eudrsgit in a sustained manner.
For such drugs it becomes essential to include hydrophobic polymers in the matrix system [ 15 ]. The authors declare that there is no conflict of interests regarding the publication of this paper.
Abstract The objective of present study was to develop an optimized polymeric eudraglt system for the antiretroviral drug tenofovir. Matrix tablets, each containing mg metformin HCl were prepared by a conventional non-aqueous wet granulation technique.
The effect of amount of polymer, surfactant concentration, and sonication time on particle size, particle distribution, eduragit efficiency EEand zeta potential were assessed and optimized utilizing a three-factor, three-level Box-Behnken Design BBD of experiment.
Department of Pharmaceutical Technology, Smt. The percentage prediction error was calculated which helps in the validation of generated regression by using 8. Figure 4 in vitro cumulative release of metformin. A stronger, wide peak was observed in the final nanoparticles without major shift in the structure of Eudragit.
From Figure 3 aa higher EE was attained with decrease in ratio of polymer to a drug and a maximum concentration of a surfactant at a constant sonication time. Tenofovir nanoparticles were prepared using modified nanoprecipitation method [ 24 ] in accordance with BBD Table 2.
Tenofovir is one of the first-line drugs used in the treatment of the human immunodeficiency virus HIV infected adults. Where R and UR are the released and unreleased percentages, respectively, at time t ; k 1k 2k 3k 4and k 5 are the rate constants of zero-order, first-order, Higuchi eudrsgit, Peppas-Korsmeyer, and Hixon-Crowell model, respectively.
Figure 2 in vitro cumulative release of metformin. Mathematical models were developed to understand the nature of the true relationship between the input variables and the output variables of the system [ 32 ].