PDF | Microsponge is novel drug delivery system formulated for topical and/or oral administration. Microsponges are po-rous microspheres. The microsponges formulations were prepared by quasi-emulsion solvent . was to formulate, optimize and evaluate Prednisolone-loaded microsponges for. Formulation and evaluation of gel-loaded microsponges of diclofenac sodium for topical delivery. Hamid Hussain, Archana Dhyani, Divya Juyal.
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Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: Based on this fact, it is probable that such an effect may lead to formularion increase in effective drug levels within the colon with a consequent increase in absorption and blood levels, i.
Formulation and in vitro—in vivo evaluation of ketoprofen-loaded albumin microspheres for intramuscular administration.
Formulation and evaluation of curcumin microsponges for oral and topical drug delivery
All other chemicals were of reagent grades and used as procured. Polymeric microsponge based system of FLZ was developed successfully using quasi-emulsion solvent diffusion method for continual topical delivery up to an formulatiion period so as to reduce application frequency, hypersensitive reactions allied to the conventional marketed formulation, and to improve bioavailability and safety.
Formulation and evaluation of microsponges for topical drug delivery of mupirocin. Optimisation of formulation parameters and formylation factors: Initial burst release observed for formulations F1 and F2 i. Int J Pharm Sci Res ; 5 5: Author information Copyright and License information Disclaimer.
The in vitro drug release showed highest regression value for the zero order model 0. Polymer ratio, higher the productions yield.
Author information Article notes Copyright and License information Disclaimer. This characteristic gives property to release the drug at a faster rate through pores and this property is very helpful to get desired drug concentration at a targeted area or blood plasma. Microencapsulation of ibuprofen and Eudragit RS by the emulsion solvent diffusion technique.
The rapid diffusion of ethanol good solvent for the polymer and drug into the aqueous medium might reduce the solubility of the polymer in the droplets, since the polymer was insoluble in the water.
A combination of the enhanced rate of adsorption and dissolution should significantly enhance drug bioavailability 11, Thus, it was found that the optimized formulation PDRS5 was stable under storage conditions Figure 9. The in-vitro dissolution studies of microsponges in the media with different pH 1.
Deb1 Riyaz Ali M. But the release rate was higher in first 2 hours due to release of non-entrapped prednisolone while the release rate was observed slower for next 6 hours.
The compatibility was checked by making physical mixture of drug and polymer 1: Int J Biopharm ; 3 2: The instrument was operated at voltage 45 mV and current 20 amp. The visual inspection of all batches using the optical microscope for particle size revealed that particle size has increased with increase in drug: In order to simulate the pH changes along the Miceosponges tract, three dissolution media with pH 1.
This is due to the fact that as a drug: Table 2 Actual drug content, encapsulation efficiency, production yield and percentage cumulative drug release.
This behavior of pure drug shows a typical peak and valley plasma concentration — time profile.
It was observed that on increasing the amount of PVA, production yield, encapsulation efficiency and particle size were increased while a slight decrease in drug release was observed [ Table 2 ]. Preparation and evaluation of microsponge loaded controlled release topical gel of acyclovir sodium. From experimental outcomes, it was concluded evaulation prepared microsponges based gel formulation exhibited promising antifungal activity.
Probably in high drug-polymer ratios less polymer amounts surround the drug and reducing the thickness of polymer wall and microsponges with smaller size were obtained. Research involving human participants and animals This article does not contain any fomulation with human and animal subjects performed by any of the authors.
Development and evaluation of voriconazole microsponges for topical delivery. Formulation and evaluation of optimized andd microsponge gel for topical delivery. Moreover, it was exposed that the distinctive internal structure comprised of spherical cavity enclosing a stiff shell assembled of drug and polymer.
The percentage drug entrapment was calculated by the following equation: Stability studies of optimized formulation: The purpose of this study was to forkulation prednisolone-loaded microsponges for colon specific drug delivery. Tri-ethyl citrate was obtained from Camport, New Delhi, India. Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells batch MS4 showed The pH of the dissolution medium was maintained at 1.
This could probably be due to the fact that in high drug to polymer ratio, microsponves amount of polymer available per microsponge was comparatively less. Fluconazole mucoadhesive buccal films: After 3 h of continuous stirring the microsponges were formed due to removal of ethyl alcohol from the system. Jain V, Singh R. Spherical microsponges with a porous surface and Formulation Spreadability diameter in cm Hardness g Adhesiveness g.
Conflicts of interest There are no conflicts of interest.